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KMID : 1039620210110050357
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Korean Journal of Family Practice
2021 Volume.11 No. 5 p.357 ~ p.364
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Comparison of Adverse Events of the First Dose and the Second Dose after Vaccination of the COVID-19 Pfizer Vaccine
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Kwon Bo-Kyeong
Park Jong-Myeong
Kim Won-Kyung
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Abstract
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Background: Among the various COVID-19 vaccines developed to counter the pandemic caused by SARS-CoV-2 virus, BNT162b2 developed by Pfizer/BioNTech was also introduced in Korea. But domestic studies on adverse events resulting from BNT162b2 are insufficient. Therefore, this study aimsto help predict and prepare for adverse events in the future to ensure safe vaccination.
Methods: A total of 139 vaccine recipients were asked to report adverse events through self-report questionnaire for a period of 10 days after dose 1and dose 2 of BNT162b2. Local and systemic adverse reactions were identified, and each adverse reaction was divided into four stages according toseverity.
Results: The onset of adverse events was significantly slower (P<0.001) and the duration was longer (P<0.001) after dose 2. The frequency and severityof all local reactions, and the frequency and severity of nausea/vomiting (P=0.005), diarrhea (P=0.002), headache (P<0.001), fatigue (P<0.001),myalgia (P<0.001), fever (P<0.001), and other reactions (P=0.003) among systemic reactions, increased after dose 2.
Conclusion: The severity and frequency of the adverse events increased after dose 2 of BNT162b2, when compared with the period after dose 1.
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KEYWORD
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COVID-19 Vaccine, MRNA (Pfizer-Biontech), Vaccine Adverse Events, Korea
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